Rosario spends the night with her grandmother's body while she waits for the ambulance to arrive, during a severe snowfall, Rosario is attacked by otherworldly entities that have taken control of her grandmother's body.
In 1905, French seminarian Bruno Reidel is found guilty of murdering a child. At the request of the doctors observing him, he writes his memoirs to explain his action.
The film tells the story of three people for a year a son (Magimel) diagnosed with cancer, a mother (Deneuve) suffering from helplessness and a doctor (Cécile de France) to do her job One year and four seasons for these three characters to deal with the disease, to tame it, and to understand what it means to die while alive.